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Lecozotan HCl

Lecozotan HCl
Lecozotan HCl (SRA-333) is a potent and selective 5-HT antagonist that significantly enhances KCl-stimulated glutamate and acetylcholine release from the hippocampal dentate gyrus and has cognitive enhancing properties. Chronic administration of Lecozotan HCl did not induce 5-HT(1A) receptor tolerance or desensitization in a behavioral model demonstrating 5-HT(1A) receptor function.
Catalog No. T27806Cas No. 433282-68-9
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Purity:99.47%
ee:98.52%
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Lecozotan HCl

Purity: 99.47%
Catalog No. T27806Alias SRA-333, SRA333, SRA 333, Lecozotan hydrochlorideCas No. 433282-68-9

Lecozotan HCl (SRA-333) is a potent and selective 5-HT antagonist that significantly enhances KCl-stimulated glutamate and acetylcholine release from the hippocampal dentate gyrus and has cognitive enhancing properties. Chronic administration of Lecozotan HCl did not induce 5-HT(1A) receptor tolerance or desensitization in a behavioral model demonstrating 5-HT(1A) receptor function.
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Pack SizePriceAvailabilityQuantity
1 mg$162In Stock
5 mg$390In Stock
10 mg$590In Stock
25 mg$943In Stock
50 mg$1,280In Stock
100 mg$1,730In Stock
500 mg$3,460In Stock
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Product Introduction

Bioactivity
Description
Lecozotan HCl (SRA-333) is a potent and selective 5-HT antagonist that significantly enhances KCl-stimulated glutamate and acetylcholine release from the hippocampal dentate gyrus and has cognitive enhancing properties. Chronic administration of Lecozotan HCl did not induce 5-HT(1A) receptor tolerance or desensitization in a behavioral model demonstrating 5-HT(1A) receptor function.
In vivo
Lecozotan HCl (0.3 mg/kg; s.c.) antagonized the decrease in hippocampal extracellular 5-HT induced by 8-hydroxy-2-dipropylaminotetralin (8-OH-DPAT) and had no effects alone at doses 10-fold higher. Lecozotan HCl significantly potentiated the potassium chloride-stimulated release of glutamate and acetylcholine in the dentate gyrus of the hippocampus. Chronic administration of Lecozotan HCl did not induce 5-HT(1A) receptor tolerance or desensitization in a behavioral model indicative of 5-HT(1A) receptor function.[1]
In drug discrimination studies, Lecozotan HCl (0.01-1 mg/kg i.m.) did not substitute for 8-OH-DPAT and produced a dose-related blockade of the 5-HT(1A) agonist discriminative stimulus cue. In aged rhesus monkeys, Lecozotan HCl produced a significant improvement in task performance efficiency at an optimal dose (1 mg/kg p.o.). Learning deficits induced by the glutamatergic antagonist MK-801 [(-)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine maleate] (assessed by perceptually complex and visual spatial discrimination) and by specific cholinergic lesions of the hippocampus (assessed by visual spatial discrimination) were reversed by Lecozotan HCl (2 mg/kg i.m.) in marmosets.[1]
AliasSRA-333, SRA333, SRA 333, Lecozotan hydrochloride
Chemical Properties
Molecular Weight520.02
FormulaC28H30ClN5O3
Cas No.433282-68-9
Storage & Solubility Information
Storagekeep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (96.15 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.9230 mL9.6150 mL19.2300 mL96.1501 mL
5 mM0.3846 mL1.9230 mL3.8460 mL19.2300 mL
10 mM0.1923 mL0.9615 mL1.9230 mL9.6150 mL
20 mM0.0962 mL0.4808 mL0.9615 mL4.8075 mL
50 mM0.0385 mL0.1923 mL0.3846 mL1.9230 mL

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